X500R QTOF system in an analytical laboratory

Stage 1 · Analyze

LC-MS applications and methods for the accredited laboratory

The right instrument, a method that stands up to audit, support for the instrument’s whole life cycle.

X500R QTOF system in an analytical laboratory

Analyze is the stage where DaSP started in 2011, as SCIEX’s official channel partner, the first in Italy. Identifying the right instrument, configuring it, building the method and optimizing it, with technical and application support for the instrument’s whole life cycle.

The result that counts is an instrument that performs every day and a method that stands up to audit.

  • SCIEX official channel partner since 2011, the first in Italy
  • 340 mass spectrometers under scientific support
  • 457 analytical methods developed in Italian laboratories
  • 229 feasibility studies

The applications, by sector

Every sector has its matrices, its analytes and its standards. DaSP works by application, not by instrument: first the analytical question, then the technology that answers it.

  • Food safety: complex matrices, legal limits, methods to validate and maintain.
  • Environment: water, soil and contaminants to be determined at ever lower concentrations.
  • Clinical and toxicology: biological samples, turnaround times, ISO 15189 requirements.
  • Pharma and biopharma: characterization, impurities, documentation that stands up to inspection.

The technologies we use

  1. Triple quadrupole systemsTargeted quantitation in complex matrices: residues, contaminants, drugs, hormones.
  2. QTRAP systemsTriple quadrupole with linear ion trap: confirmation and quantitation in the same method.
  3. QTOF and high-resolution systemsScreening of unknowns, characterization, accurate-mass confirmation.
  4. Echo MS+Sample introduction without chromatography, for high-throughput analysis.
  5. LC systemsExionLC liquid chromatography, from routine methods to microflow.
  6. SoftwareSCIEX OS for acquisition and processing; instrument status monitoring software.
Amber vials on the autosampler tray

XIC · MRM

Chromatograms of five steroids: the SCIEX 7500+ system and the QTRAP 6500+ system comparedData: SCIEX, official application material
Five steroid chromatograms compared between the SCIEX 7500+ system and the QTRAP 6500+ system, with area gain and signal-to-noise ratio

Chromatograms of five steroids: the SCIEX 7500+ system and the QTRAP 6500+ system compared · Data: SCIEX, official application material

The SCIEX ExionLC AE system, official render
The ExionLC AE system

Pages in this stage

Treatment of a farm field: where the samples for residue analysis come from

Analytical applications by sector

Food safety, environment, clinical and toxicology, pharma and biopharma: the analytical challenge and the DaSP approach, sector by sector.

Pipetting samples at the preparation bench

Analytical methods

Feasibility studies, optimization, development and validation according to ISO/IEC 17025: protocol, validation dossier, method transfer.

LC-MS system installed in the laboratory

Support and engineering

Technical and application support for the instrument’s whole life cycle, maintenance, laboratory engineering and automation.

The questions we get asked

Why not buy directly from the manufacturer?

Because the instrument is the beginning, not the end. DaSP stays alongside the laboratory for the instrument’s whole life cycle: the method is built and transferred, people are trained, and there is a single point of contact for instrument, method and support.

Do you develop the method, or do we?

Together. DaSP builds the method with the laboratory, documents it and transfers it to the people who will use it. Internal validation remains the laboratory’s: DaSP prepares it, it does not replace it.

A method stands up to audit when the quality system holds too. For accreditation and training, there is the Grow stage.

Laboratory internal audit

Not sure where to start? The laboratory internal audit gives you the audit report and the process map. It is worth €600: for the time being we offer it free of charge.

Book an AUDIT